期刊
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
卷 128B, 期 1, 页码 30-36出版社
WILEY
DOI: 10.1002/ajmg.b.30030
关键词
eye tracking; schizophrenia; latent trait model; chromosome 6p; linkage
资金
- NIGMS NIH HHS [R01 GM 57453] Funding Source: Medline
- NIMH NIH HHS [R01 MH 59513, K05 MH 01021, R01 MH031340, R01 MH 31340, P01 MH 31154, R37 MH 44876, R01 MH 49487, R01 MH049487] Funding Source: Medline
- NINDS NIH HHS [NS 16367, NS 036711] Funding Source: Medline
Establishing the genetics of physiological traits associated with schizophrenia may be an important first step in building a neurobiological bridge between the disease phenotype and its genetic underpinnings. One of the best known of the traits associated with schizophrenia is a disorder of smooth pursuit eye tracking (ETD), which is present in 50-80% of schizophrenia patients. ETD is more than three times more prevalent in the families of a schizophrenia patient than is schizophrenia itself. Arolt et al. [1999] estimated LOD scores for ETD of 2.85 for D6S282 and 3.70 for D6S271, two markers on 6p21.1, as well as obtaining an indication of possible linkage for schizophrenia. Our sample comprised two large families in Denmark. Markers in the region that was implicated by the study of Arolt et al. [1996, 1999] were analyzed as part of a genome scan using the latent trait (L.T.) model for the co-transmission of schizophrenia and ETD that we had previously fitted to segregation analysis data from Norway. We obtained a LOD score of 2.05 for D6S1017, a marker within 3 cM of the positive markers obtained by Arolt et al. [1996, 1999]. We regard our results as independent evidence supporting the findings of Arolt et al. [1996, 1999] and also as support for the L.T. model as a way of combining the traits ETD and schizophrenia. (C) 2004 Wiley-Liss, Inc.
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