期刊
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
卷 1700, 期 1, 页码 27-34出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbapap.2004.03.006
关键词
human serum albumin; activation energy; effective specific volume; intrinsic viscosity; huggins coefficient
The paper presents the results of viscosity determinations on aqueous solutions of human serum albumin (HSA) at a wide range of concentrations and at temperatures ranging from 5 to 45 degreesC. On the basis of a modified Arrhenius formula and Mooney's equation, the viscosity-temperature and viscosity-concentration dependence of the solutions are discussed. The effective specific volume, the activation energy and entropy of viscous flow for hydrated HSA were calculated. Different models of HSA molecule are discussed and the best one-from the hydrodynamic point of view-was established. At low concentration limit, such theological quantities as the intrinsic viscosity and Huggins coefficient were obtained. Using the dimensionless parameter [eta]c, the existence of three characteristic ranges of concentrations: diluted, semi-diluted and concentrated, was shown. (C) 2004 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据