期刊
INFECTION AND IMMUNITY
卷 72, 期 7, 页码 4297-4301出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.72.7.4297-4301.2004
关键词
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Loss of the transcriptional antiterminator RfaH results in virulence attenuation (>10(4)-fold increase in 50% lethal dose) of the archetypal Salmonella enterica serovar Typhimurium strain SL1344 by both orogastric and intraperitoneal routes of infection in BALB/c mice. Oral immunization with the mutant efficiently protects mice against a subsequent oral infection with the wild-type strain. Interestingly, in vitro immunoreactivity is not confined to strain SL1344; rather, it is directed also towards other serovars of S. enterica and even Salmonella bongori strains.
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