期刊
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
卷 52, 期 7, 页码 959-965出版社
SAGE PUBLICATIONS LTD
DOI: 10.1369/jhc.4A6277.2004
关键词
slug protein; gene expression; histocytochemistry; immunohistochemistry; mouse
类别
资金
- NCI NIH HHS [CA89216] Funding Source: Medline
- NICHD NIH HHS [HD34883] Funding Source: Medline
The Slug transcription factor plays an important role in epithelial-mesenchymal transformation during embryogenesis and is expressed in adult tissues during carcinogenesis. By detecting expression of a Slug-beta-galactosidase fusion protein, we have now demonstrated that Slug is also re-expressed in a variety of normal tissues in the adult mouse. Slug is expressed at relatively high levels in patchy stretches of basal cells in stratified and pseudostratified epithelium, including skin, oral mucosa, esophagus, stomach, rectum, cervix, and trachea. Slug is also found at variable levels in fibroblasts and stromal smooth muscle cells in many tissues. Sites of more intense Slug expression in mesenchymal tissues include cartilage, kidney glomeruli, lung, ovary, and uterus. Therefore, Slug expression is not restricted to the period of embryonic development or to pathological processes. The pattern of localization to basal cells in various epithelia suggests that Slug may play a role in the cell migration that occurs during continual renewal of these tissues.
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