期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 24, 期 7, 页码 826-828出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.WCB.0000126565.27130.79
关键词
T scripta; turtle; anoxia; heat shock proteins; brain; protection
Because heat shock proteins (HSPs) have an important protective function against ischemia/anoxia in mammalian brain, the authors investigated the expression of Hsp72 and Hsc73 in the anoxia-surviving turtle brain. Unlike the mammalian brain, high levels of Hsp72 were found in the normoxic turtle brain. Hsp72 levels were significantly increased by 4 hours of anoxia, remained constant until 8 hours, and then decreased to baseline at 12 hours. By contrast, Hsc73 was progressively increased throughout 12 hours of anoxia. This differential expression suggests different protective roles: Hsp72 in the initial downregulatory transition phase, and Hsc73 in maintaining neural network integrity during the long-term hypometabolic phase.
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