期刊
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
卷 118, 期 1-3, 页码 215-232出版社
HUMANA PRESS INC
DOI: 10.1385/ABAB:118:1-3:215
关键词
genomewide gene expression analysis; DNA chips; DNA microarrays; cluster analysis; global regulatory mechanisms; amino acid production; Corynebacterium glutamicum; Escherichia coli
DNA microarray technology has become an important research tool for biotechnology and microbiology. It is now possible to characterize genetic diversity and gene expression in a genomewide manner. DNA microarrays have been applied extensively to study the biology of many bacteria including Escherichia coli, but only recently have they been developed for the Grampositive Corynebacterium glutamicium. Both bacteria are widely used for biotechnological amino acid production. In this article, in addition to the design and generation of microarrays as well as their use in hybridization experiments and subsequent data analysis, we describe recent applications of DNA microarray technology regarding amino acid production in C. glutamicum and E. coli. We also discuss the impact of functional genomics studies on fundamental as well as applied aspects of amino acid production with C. glutamicum and E. coli.
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