期刊
JOURNAL OF PHARMACOLOGICAL SCIENCES
卷 95, 期 3, 页码 374-380出版社
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.FPJ04014X
关键词
SNC80; delta-opiold receptor; forced swimming test; conditioned fear stress test; elevated plus-maze
In the present study, we investigated the antidepressant- and anxiolytic-like effects of (+)-4-[(aR)-a-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80), a non-peptidic selective delta-opioid receptor agonist, in various animal models in rodents. SNC80 significantly reduced the duration of immobility in the forced swimming test. Furthermore, in the elevated plus-maze test, SNC80 dose-dependently and significantly increased the time spent in the open arms of the plus-maze. These effects were completely antagonized by a selective delta-opioid-receptor antagonist, naltrindole. In the conditioned fear stress test, which examines psychological stress-induced motor suppression, desipramine did not produce any significant effect on the conditioned suppression of locomotor activity. However, SNC80 completely attenuated the conditioned suppression of locomotor activity in the conditioned fear stress test. In conclusion, our results suggest that delta-opioid receptors
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