期刊
TOXICOLOGIC PATHOLOGY
卷 32, 期 4, 页码 426-438出版社
SAGE PUBLICATIONS INC
DOI: 10.1080/01926230490462138
关键词
PTH; teriparatide; rat; bone; neoplasms; osteoporosis treatment; osteosarcoma
A long-term study was conducted in female F344 rats to determine the relative importance of dose, treatment duration, and age at initiation of treatment on the incidence of teriparatide [rhPTH[1-34)]-induced bone proliferative lesions. Treatment groups consisted of different combinations of dose (0, 5, or 30 mug/kg/d), treatment duration (6, 20, or 24 months) and age at initiation of treatment ( 2 or 6 months of age). The primary endpoints were the incidence of bone neoplasms and effects on bone mass and structure as evaluated by quantitative computed tomography and histomorphometery. Significant increases in the incidence of bone tumors (osteoma, osteoblastoma, and osteosarcoma) occurred in rats treated with 30 mug/kg for 20 or 24 months. No neoplasms were found when the 5 mug/kg treatment was initiated at 6 months of age and continued for either 6 or 20 months ( up to 70% of life span). This treatment regimen defined a no-effect dose for neoplasm formation that nevertheless resulted in substantial increases in bone mass. These results demonstrate that treatment duration and administered dose are the most important factors in the teriparatide-induced bone tumors in rats.
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