期刊
JOURNAL OF INFECTIOUS DISEASES
卷 190, 期 1, 页码 72-82出版社
UNIV CHICAGO PRESS
DOI: 10.1086/421277
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Immunity to childhood diseases is maintained for decades by mechanisms that, at present, are still unclear. We longitudinally studied immune responses in 16 adults exposed to children experiencing varicella ( chicken pox). None of the individuals showed clinical signs of infection, and varicella-zoster virus (VZV) DNA could not be detected in peripheral blood or cultured from nasopharyngeal swabs. Exposure to VZV, however, induced expansion of antigen-specific CD4(+) T cells in peripheral blood, with concomitant changes in cytotoxic CD8(+) T cells and natural killer cells. VZV-specific memory CD4(+) T cells were uniformly CD45RA(-) and enriched for CD27(-) cells. The virus-specific cells produced interferon-gamma, tumor necrosis factor-alpha, and interleukin-2. These memory responses to VZV were compared with the primary immune responses of children experiencing varicella. VZV-specific memory CD4(+) T cell responses largely resemble the primary immune response to VZV.
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