期刊
DEVELOPMENTAL DYNAMICS
卷 230, 期 3, 页码 557-568出版社
WILEY
DOI: 10.1002/dvdy.20052
关键词
ADAM; metalloprotease; disintegrin; epithelium; lens; myogenesis; morphogenesis
Members of the ADAM (a disintegrin and metalloprotease) family are involved in fertilization, morphogenesis, and pathogenesis. Their metalloprotease domains mediate limited proteolysis, including ectodomain shedding of membrane-anchored growth factors and intercellular-signaling proteins, and their disintegrin domains play regulatory roles in cell adhesion and migration. In screening for cDNAs encoding chicken ADAM proteins expressed during muscle development, we identified Meltrin E as a novel member of this family. To elucidate its functions, we investigated its expression during development by using antibodies raised against its protease domain. In the somites, Meltrin epsilon protein was specifically expressed in the myotomal cells, which delaminate from the dermomyotome to form epithelial sheets. It was also found in the surface ectoderm, lens placodes, otic vesicles, and the gut epithelia. Basolateral localization of Meltrin E in these epithelial cells suggests its unique roles in the organization of the epithelial tissues and development of the sensory organs and the gut. (C) 2004 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据