期刊
AMERICAN JOURNAL OF PSYCHIATRY
卷 161, 期 7, 页码 1290-1292出版社
AMER PSYCHIATRIC PRESS, INC
DOI: 10.1176/appi.ajp.161.7.1290
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资金
- NIMH NIH HHS [MH 30915, R01 MH 60335, R01 MH 57375] Funding Source: Medline
Objective: The authors attempted to reduce the rate of postpartum depression in high-risk women and to increase the time to recurrence. Method: Nondepressed pregnant women with at least one past episode of postpartum major depression were recruited into a randomized clinical trial. Mothers were assigned randomly to a 17-week trial of sertraline or placebo immediately after birth and assessed for 20 sequential weeks with the Hamilton Rating Scale for Depression. Results: Of 14 subjects who took sertraline, one (7%) suffered a recurrence. Of eight subjects who were assigned to placebo, four (50%) suffered recurrences. This difference was significant. The time to recurrence was significantly longer in the sertraline-treated women than in the placebo-treated women. Conclusions: Sertraline conferred preventive efficacy for postpartum-onset major depression beyond that of placebo.
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