期刊
APPLIED SURFACE SCIENCE
卷 258, 期 18, 页码 6823-6830出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2012.03.109
关键词
Hydroxyapatite; PLLA; Nanohybrids; ATRP; Biomineralization
类别
资金
- National Basic Research Program of China [2012CB933904]
- National High Technology Research and Development Program of China [2011AA030102]
- National Natural Science Foundation of China [51073016, 51173014]
- Program for New Century Excellent Talents in University [NCET-11-0556, NCET-10-0203]
It is important to improve the compatibility of hydroxyapatite (HA) nanoparticles in biodegradable polyesters to obtain desirable nanocomposites for bone tissue engineering applications. Polymer grafting has been proven an efficient way to get nanohybrids with good dispersibility in polymeric matrixes. In this paper, a new strategy to prepare HA-poly(l-lactide) (PLLA) nanohybrids was developed, where PLLA oligomers were grafted from HA nanoparticle surfaces via surface-initiated atom transfer radical polymerization (ATRP) of methylacrylate group terminated PLLA macromonomers (PLLA-MA). HA with the derived ATRP initiators was obtained by (1) preparation of HA from precursors in the presence of 3aminopropyl- triethoxysilane (APTS) to produce the HA surface with terminal NH2 groups (HA-NH2) and ((2)) reaction of the NH2 groups of the HA-NH2 nanoparticles with (2)-bromoisobutyryl bromide (BIBB) to produce the (2)-bromoisobutyryl-immobilized nanoparticles (HA-Br). The obtained HA-PLLA nanohybrids demonstrated good dispersibility in chloroform. With the good dispersion of HA-PLLA nanohybrids in PLLA matrix, the resultant PLLA/HA-PLLA nanocomposites could much faster induce bone-like apatite-formation in simulated body fluids (SBF) than the PLLA/HA counterparts where the HA nanoparticles aggregated heavily. With the versatility of ATRP, properly, grafting oligomeric PLLA chains from HA nanoparticle surfaces is an effective means for the design of novel HA-polymer biohybrids for future bone tissue engineering applications. (C) 2012 Elsevier B. V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据