期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 48, 期 7, 页码 2693-2696出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.48.7.2693-2696.2004
关键词
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Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 muM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.
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