期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 47, 期 14, 页码 3697-3699出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm030555f
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资金
- NCI NIH HHS [CA 70369] Funding Source: Medline
- NIGMS NIH HHS [GM 07775] Funding Source: Medline
Epi-C3-cryptophycin-24, epi-C3-m-chlorobenzyl-cryptophycin-24, and the corresponding styrenes were synthesized and tested in vitro against the MCF-7 and multidrug-resistant MCF-7/ADR breast cancer cell lines and in an in vitro tubulin assembly assay. The results demonstrate that the S configuration at the C3 stereocenter is not required to induce potent cytotoxicity and the m-Cl substituent present on the C10 side chain did not induce any large change in activity.
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