期刊
FEBS LETTERS
卷 569, 期 1-3, 页码 301-306出版社
WILEY
DOI: 10.1016/j.febslet.2004.05.077
关键词
glutathione peroxidase; calcineurin; Crz1; yeast; Ca2+ signaling
The GPX2 gene encodes a homologue of mammalian phospholipid hydroperoxide glutathione peroxidase in Saccharomyces cerevisiae. Previously, we have reported that the oxidative stress-induced expression of GPX2 is strictly regulated by Yap1 and Skn7 transcription factors. Here, we found that the expression of GPX2 is induced by CaCl2 in a calcineurin (CN)/ Crz1-dependent manner, and the CN-dependent response element was specified in the GPX2 promoter. Neither Yap1 nor Skn7 was required for Ca2+-dependent induction of GPX2, therefore, distinct regulation for the oxidative stress response and Ca2+ signal response for GPX2 exists in yeast cells. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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