期刊
FEBS LETTERS
卷 569, 期 1-3, 页码 99-104出版社
WILEY
DOI: 10.1016/j.febslet.2004.05.056
关键词
CXCR4 antagonist; rheumatoid arthritis; T140; collagen-induced arthritis; delayed-type hypersensitivity
Several recent papers support the involvement of an interaction between stromal cell-derived factor-1 (SDF-1/ CXCL12) and its receptor, chemokine receptor CXCR4, in memory T cell migration in the inflamed rheumatoid arthritis (RA) synovium. Analogs of the 14-mer peptide T140 were previously found to be specific CXCR4 antagonists that were characterized as not only HIV-entry inhibitors but also anticancer-metastatic agents. In this study, a T140 analog, 4F-benzoyl-TN14003, was proven to inhibit CXCL12-mediated migration of human Jurkat cells and mouse splenocyte in a dose-dependent manner in vitro (IC50 = 0.65 and 0.54 nM, respectively). Furthermore, slow release administration by subcutaneous injection (s.c.) of 4F-benzoyl-TN14003 using an Alzet osmotic pump significantly suppressed the delayed-type hypersensitivity response induced by sheep red blood cells in mice, and significantly ameliorated clinical severity in collagen-induced arthritis in mice. As such, T140 analogs might be attractive lead compounds for chemotherapy of RA. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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