期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 279, 期 27, 页码 28670-28674出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M402558200
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资金
- NIAMS NIH HHS [AR 40197] Funding Source: Medline
- NIA NIH HHS [AG 17241, AG 15052] Funding Source: Medline
- PHS HHS [HE 23641] Funding Source: Medline
Obesity is a risk factor for the development of cardiovascular diseases that are associated with impaired angiogenesis. Adiponectin is an adipocyte-specific adipocytokine with anti-atherogenic and anti-diabetic properties, and its plasma levels are reduced in association with obesity-linked diseases. Here, we investigated whether adiponectin regulates angiogenesis in response to tissue ischemia using adiponectin knock-out ( KO) mice. Angiogenic repair of ischemic hind limbs was impaired in adiponectin-KO mice compared with wildtype (WT) mice as evaluated by laser Doppler flow method and capillary density analyses. Adenovirus-mediated supplement of adiponectin accelerated angiogenic repair in both adiponectin-KO and WT mice. Intramuscular injection of an adenovirus encoding dominant-negative AMP-activated kinase diminished the improvement in limb perfusion seen in WT mice and abolished the adiponectin-induced enhancement of perfusion. These data indicate that adiponectin can function to stimulate angiogenesis in response to ischemic stress by promoting AMP-activated kinase signaling. Therefore, adiponectin may be useful in the treatment for obesity-related vascular deficiency diseases.
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