期刊
FEBS LETTERS
卷 569, 期 1-3, 页码 235-239出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2004.05.072
关键词
hepatocyte; lipopolysaccharide; toll-like receptor; serum amyloid A protein
To investigate the role of lipopolysaccharide (LPS) in hepatocyte activation, we examined the expression of Toll-like receptor 4 (TLR4), the putative receptor for LPS in human hepatocytes. TLR4 mRNA and protein expression was confirmed in human hepatocytes. Stimulation of human hepatocytes with LPS results in rapid degradation of IkappaB-a and mitogen activated protein kinase activation. Human hepatocytes stimulated by LPS produced serum amyloid A protein. Our data suggest that human hepatocytes utilize components of TLR4 signal transduction pathways in response to LPS and these direct LPS-mediated effects on hepatocytes may contribute to liver inflammation and injury. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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