期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 10, 期 13, 页码 3130-3138出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200400363
关键词
azo compounds; combinatorial chemistry; Mitsunobu reaction; perfluorinated compounds; solid-phase synthesis
The Mitsunobu reaction is famous for its scope and power, but infamous for its separation headaches. Typically, the target product is enticed away from the reagent-derived byproducts by careful chromatography. ne use of polymer-bound Mitsunobu reagents solves only half of the problem, because polymer-bound diethyl azodicarboxylate (DEAD) and phosphine reagents cannot be employed simultaneously. This article classifies, compares, and contrasts various emerging strategies for product isolation in Mitsunobu reactions. Because so many different strategies have been used, the Mitsunobu reaction is a microcosm for the new field of strategy level separations.
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