期刊
APPLIED SURFACE SCIENCE
卷 257, 期 12, 页码 5456-5459出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2010.11.010
关键词
Gold nanoparticles; Plasmons; Photothermal therapy
类别
资金
- Bulgarian National Science Found [DO 02-293]
Theoretical and experimental results on the heating process of gold nanoparticles irradiated by nanosecond laser pulses are presented. The efficiency of particle heating is demonstrated by in-vitro photothermal therapy of human tumor cells. Gold nanoparticles with diameters of 40 and 100nmare added as colloid in the cell culture and the samples are irradiated by nanosecond pulses at wavelength of 532nm delivered by Nd:YAG laser system. The results indicate clear cytotoxic effect of application of nanoparticle as more efficient is the case of using particles with diameter of 100 nm. The theoretical analysis of the heating process of nanoparticle interacting with laser radiation is based on the Mie scattering theory, which is used for calculation of the particle absorption coefficient, and two-dimensional heat diffusion model, which describes the particle and the surrounding medium temperature evolution. Using this model the dependence of the achieved maximal temperature in the particles on the applied laser fluence and time evolution of the particle temperature is obtained. (C) 2010 Elsevier B.V. All rights reserved.
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