期刊
APPLIED SURFACE SCIENCE
卷 257, 期 9, 页码 4133-4138出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2010.12.011
关键词
Electrospinning; Tissue engineering; Nanofibrous scaffold; Natural polymer; Synthetic polymer
类别
资金
- National High Technology Research and Development Program of China [2007AA03Z429]
Electrospun blended nanofibrous scaffolds were fabricated from an synthetic biodegradable polymer (poly(L-lactide-co-epsilon-caprolactone): PLCL; 8% solution) and a natural protein (fibrinogen; 100 mg/ml solution) with different volume ratios. Results showed that the blended scaffolds consisted of nanoscale fibers with mean diameters ranging from 224 to 450 nm. The deposition of the fibrinogen amino groups on the surfaces of the blended scaffolds was confirmed by XPS. The hydrophilicity of the blended scaffolds were improved with the fibrinogen content increasing in the blended system. Cell viability assay and SEM results showed that human umbilical vein endothelial cells (HUVECs) had progressive growth and well spread morphology on the blended scaffolds. This study demonstrated that electrospun PLCL/fibrinogen blended scaffolds have potential application in tissue engineering. (C) 2010 Elsevier B.V. All rights reserved.
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