期刊
NEUROLOGY
卷 63, 期 1, 页码 170-172出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.WNL.0000133133.77952.7C
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资金
- NIBIB NIH HHS [EB01015] Funding Source: Medline
- NINDS NIH HHS [NS29029, NS37739] Funding Source: Medline
The metabolic changes in the deep gray matter (GM) nuclei, thalamus, and basal ganglia of patients with relapsing-remitting multiple sclerosis were investigated with quantitative, multivoxel, three-dimensional proton MR spectroscopy. This technique facilitated the study of several bilateral structures in a single session at sub-cubic centimeter spatial resolution. Compared with 9 matched control subjects, the deep GM nuclei of 11 patients showed 7% lower N-acetylaspartate and 14% higher choline levels (p = 0.02 for both).
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