期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 495, 期 2-3, 页码 201-208出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2004.05.031
关键词
angiogenesis; antiinflammatory; genipin; inducible nitric oxide synthase; lipid peroxidation; NO (Nitric oxide)
Genipin, the aglycone of geniposide, is metabolically produced from the geniposide in body tissues. The purpose of this study is to clarify some pharmacological actions of genipin. Genipin showed concentration-dependent inhibition on lipid peroxidation induced by Fe++/ ascorbate in rat brain homogenate. Genipin exhibited significant topical antiinflammatory effect shown as an inhibition of croton oil-induced ear edema in mice. Nitric oxide (NO) synthesis by inducible nitric oxide synthase (NOS) is increased in inflammatory diseases and leads to cellular injury. Genipin concentration-dependently (50-300 muM) inhibited NO production and NOS expression upon stimulation by lipopolysaccharide/interferon-gamma (IFN-gamma) in RAW 264.7, a murine macrophage cell line. Genipin markedly blocked lipopolysaccharide-evoked degradation of inhibitor-kappaB-beta (IkappaB-beta), indicating that it exhibits inhibitory effect on NO production through the inhibition of nuclear factor-kappaB (NF-kappaB) activation. It was also shown to contain potent antiangiogenic activity in a dose-dependent manner, which was detected by chick embryo chorioallantoic membrane assay. In summary, we demonstrate that genipin possesses antiinflammatory and is a specific hydroxyl radical scavenger. Its antiangiogenic and NO production-inhibitory properties are also presented. (C) 2004 Elsevier B.V. All rights reserved.
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