期刊
BIOLOGICAL PSYCHIATRY
卷 56, 期 2, 页码 67-71出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2003.11.019
关键词
dopamine; reward; expectation; Parkinson's disease; placebo effect; probability
Recent evidence indicates that the placebo effect in Parkinson's disease is mediated by the release of dopamine in the dorsal striation. Interestingly. there is also placebo-induced dopamine release in the ventral striatum which establishes a connection between, the placebo effect and reward mechanisms. Specifically, we propose that placebo responses are related to the activation of the reward circuitry. Here, the clinical benefit induced by placebos represents the reward. The magnitude of the placebo effect likely depends on the a priori probability of clinical benefit. This notion has profound implications in the design, of clinical trials and placebo investigations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据