期刊
NEUROSCIENCE LETTERS
卷 365, 期 1, 页码 28-32出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2004.04.051
关键词
Alzheimer disease; mtDNA; mitochondrial haplogroups; APOE
资金
- NCRR NIH HHS [RR00856] Funding Source: Medline
- NIA NIH HHS [AG10123, AG05128, U24 AG021886, AG09029, AG019726, AG11268] Funding Source: Medline
- NIMH NIH HHS [MH59528, MH52453] Funding Source: Medline
- NINDS NIH HHS [NS31153] Funding Source: Medline
We examined the association of mtDNA variation with Alzheimer disease (AD) risk in Caucasians (989 cases and 328 controls) testing the effect of individual haplogroups and single nucleotide polymorphisms (SNPs). Logistic regression analyses were used to assess risk of haplogroups and SNPs with AD in both main effects and interaction models. Males classified as haplogroup U showed an increase in risk (OR = 2.30; 95% CI, 1.03-5.11; P = 0.04) of AD relative to the most common haplogroup H, while females demonstrated a significant decrease in risk with haplogroup U (OR = 0.44; 95% CI, 0.24-0.80; P = 0.007). Our results were independent of APOE genotype, demonstrating that the effect of mt variation is not confounded by APOE4 carrier status. We suggest that variations within haplogroup U may be involved in AD expression in combination with environmental exposures or nuclear proteins other than APOE. (C) 2004 Published by Elsevier Ireland Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据