期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 14, 期 14, 页码 3771-3774出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.04.098
关键词
combretastatins; quinolines; tubulin polymerization inhibition
The 3-hydroxy-4-methoxyphenyl ring of combretastatin A-4 can be replaced by a 2-naphthyl moiety without significant loss of cytotoxicity and inhibition of tubulin polymerization potency. In this paper we show that the 6- or 7-quinolyl systems can in turn replace both cyclic moieties, keeping in the first case most of the potency as cytotoxic agent and in the second case as inhibitor of tubulin polymerization, related to the activities displayed by model compounds. (C) 2004 Elsevier Ltd. All rights reserved.
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