Synthesis and antiangiogenic activity of exo-olefinated deoxoartemisinin derivatives

10-exo-Bromoalkylidene and benzylidene deoxoarternisinin derivatives with antiangiogenic activity were synthesized from corresponding 10-alkanesulfonyl dihydroartemisinin and 10-phenylmethanesulfonyl dihydroartemisinin using a highly efficient, mild, and simple Ramberg-Backlund rearrangement. (C) 2004 Elsevier Ltd. All rights reserved.