期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 101, 期 29, 页码 10602-10607出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0404100101
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资金
- NCI NIH HHS [CA87637, R01 CA087637] Funding Source: Medline
Persistently activated Stat3 is found in many different cancers, including approximate to60% of breast tumors. Here, we demonstrate that a constitutively activated Stat3 transforms immortalized human mammary epithelial cells and that this oncogenic event requires the activity of matrix metalloproteinase-9 (MMP-9). By immunohistochemical analysis, we observe a positive correlation between strong MMP-9 expression and tyrosine phosphorylated Stat3 in primary breast cancer specimens. These results demonstrate a relationship between activated Stat3 and MMP-9 in breast oncogenesis.
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