期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 126, 期 28, 页码 8702-8709出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja040022b
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资金
- NCI NIH HHS [CA88310, CA94166] Funding Source: Medline
- NCRR NIH HHS [1S10RR16659] Funding Source: Medline
The nuclease hypersensitivity element III1 (NHE III1) upstream of the P1 and P2 promoters of c-MYC controls 80-90% of the transcriptional activity of this gene. The purine-rich strand in this region can form a G-quadruplex structure that is a critical part of the silencer element for this promoter. We have demonstrated that this G-quadruplex structure can form a mixture of four biologically relevant parallel-loop isomers, which upon interaction with the cationic porphyrin TMPyP4 are converted to mixed parallel/antiparallel G-quadruplex structures.
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