期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 126, 期 28, 页码 8710-8716出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja048805k
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资金
- NCI NIH HHS [P30 CA008748] Funding Source: Medline
- NIGMS NIH HHS [GM34504, P41 GM066354, R01 GM034504] Funding Source: Medline
The nuclease-hypersensitivity element III1 in the c-myc promoter is a good anticancer target since it largely controls transcriptional activation of the important c-myc oncogene. Recently, the guanine-rich strand of this element has been shown to form an equilibrium between G-quadruplex structures built from two different sets of G-stretches; two models of intramolecular fold-back antiparallel-stranded G-quadruplexes, called basket and chair forms, were proposed. Here, we show by NMR that two sequences containing these two sets of G-stretches form intramolecular propeller-type parallel-stranded G-quadruplexes in K+-containing solution. The two structures involve a core of three stacked G-tetrads formed by four parallel G-stretches with all anti guanines and three double-chain-reversal loops bridging three G-tetrad layers. The central loop contains two or six residues, while the two other loops contain only one residue.
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