期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 475, 期 3, 页码 361-373出版社
WILEY
DOI: 10.1002/cne.20164
关键词
visual areas; intracortical connections; short-term plasticity; synaptic depression; excitation; inhibition
资金
- NEI NIH HHS [EY05935] Funding Source: Medline
- NINDS NIH HHS [NS30676] Funding Source: Medline
Recordings of synaptic responses of pyramidal, neurons to feedback (FB) inputs from higher to lower areas of visual cortex show that excitatory synaptic responses are only weakly opposed by disynaptic inhibition. Whether weak inhibition is preserved at high frequencies rernains unknown. Whole cell recordings were performed in pyramidal cells of mouse visual cortex to study the frequency dependence of excitatory and inhibitory postsynaptic currents (EPSCs, IPSCs) elicited by feedforward (FF) input from the primary visual cortex (V1) to the higher lateromedial area (LM) and by FB input from the LM to V1. EPSCs showed similar frequency dependencies in FF and FB pathways; the amplitudes decreased during stimulus trains, and the depression was larger at higher frequencies. IPSCs decreased during repetitive stimulation, and the depression increased at higher frequencies. At > 20 Hz, the depression of IPSCs in the FB pathway was greater than in the FF pathway. Thus, unlike FF circuits, FB circuits provide balanced excitatory and inhibitory inputs across a Wide range of frequencies. This property was shown to be critically important in cortical circuits that modulate the gain of pyramidal cell firing (Chance et al. [2002] Neuron 35:773-782). (C) 2004 Wiley-Liss, Inc.
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