期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 32, 期 -, 页码 640-642出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0320640
关键词
C-terminus of Hsc70-interacting protein (CHIP); heat-shock protein 70 (Hsp70); HSJ1a; rhodopsin; ubiquitin-interacting motif (UIM); ubiquitin-proteasome system
The heat-shock protein 70 chaperone machine is functionally connected to the ubiquitin-proteasome system by the co-chaperone CHIP. In this article, we discuss evidence that the neuronal Dnaj proteins HSJ1a and HSJ1b may represent a further link between the cellular protein folding and degradation machineries. We have demonstrated that HSJ1 proteins contain putative ubiquitin interaction motifs and can modulate the cellular processing of rhodopsin, a protein that is targeted for degradation by the proteasome when it is misfolded.
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