期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 61, 期 16, 页码 2100-2112出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-004-4222-9
关键词
SARS; SARS-CoV; coronavirus; intestine; Caco-2; CL-14; microarray
To identify a model for the study of intestinal pathogenesis of severe acute respiratory syndrome (SARS) we tested the sensitivity of six human intestinal epithelial cell lines to infection with SARS coronavirus (SARS-CoV). In permissive cell lines, effects of SARS-CoV on cellular gene expression were analysed using high-density oligonucleotide arrays. Caco-2 and CL-14 cell lines were found to be highly permissive to SARS-CoV, due to the presence of angiotensin-converting enzyme 2 as a functional receptor. In both cell lines, SARS-CoV infection deregulated expression of cellular genes which may be important for the intestinal pathogenesis of SARS.
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