Poly(D,L-lactide-ran-ε-caprolactone)-poly(ethylene glycol)-poly(D,L-lactide-ran-ε-caprolactone) as parenteral drug-delivery systems

P(DLA(chi)-ran-CLY)(n)-b-PEG-b-P(DLA(chi)-ran-CLY)(n)s (P(DLA(chi)-ran-CLY)(m): Poly(D,L-lactide-ran-epsilon-caprolactone), PEG: Poly(ethylene glycol), X: D,L-lactyl unit ratio, Y: epsilon-caproyl unit ratio, m: molecular weight of P(DLA(chi)-ran-CLY)), were investigated as the novel parenteral drug-delivery system. The thermal behavior in the DSC characterization and variable viscosity with temperature suggest their potential usuage as a injectable drug-delivery system. The variation of tri-block structure affects the drug release behavior by changing the morphology and also by changing the interaction between the polymer matrix and the hydrophilic drug. (C) 2003 Elsevier Ltd. All rights reserved.