期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 11, 期 8, 页码 797-798出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb804
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epsilon-Toxin from Clostridium perfringens is a lethal toxin. Recent studies suggest that the toxin acts via an unusually potent pore-forming mechanism. Here we report the crystal structure of epsilon-toxin, which reveals structural similarity to aerolysin from Aeromonas hydrophila. Pore-forming toxins can change conformation between soluble and transmembrane states. By comparing the two toxins, we have identified regions important for this transformation.
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