期刊
TOXICOLOGICAL SCIENCES
卷 80, 期 2, 页码 225-229出版社
OXFORD UNIV PRESS
DOI: 10.1093/toxsci/kfh159
关键词
mechanism; DNA reactive; non-genotoxic; estrogen; immunosuppressive; cell proliferation
类别
An approach to the evaluation of carcinogenic risk resulting from exposure to a given chemical is presented in place of a reliance on two-year rodent bioassays. An emphasis is placed on evaluation of the potential DNA reactivity or increased cell proliferation that can be produced by a chemical. The special cases of immunosuppressive and estrogenic chemicals are considered. These evaluations are proposed to involve a combination of in vitro assays, computerized models, and short-term (up to 13 weeks) bioassays in rodents. The emphasis is on mechanistic understanding and evaluation of the dose response and relevance to humans.
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