期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 93, 期 8, 页码 1962-1979出版社
ELSEVIER SCIENCE INC
DOI: 10.1002/jps.20096
关键词
polymeric prodrugs; polymer-drug conjugate; passive drug targeting; controlled release; hydrolysis; intramolecular reaction
Polymeric prodrugs have evolved into a very useful class of drug delivery agents. Numerous polymeric prodrugs have been prepared for applications ranging from passive drug targeting to controlled release. The mechanistic aspects of the release processes, however, have not been clearly delineated. This review highlights the salient features of the chemical reactions that are responsible for drug release from these systems. The mechanisms of release from polymeric prodrugs employing various chemical linkages, esters, carbonates, carbamates, C=N linkage and amides, are discussed. (C) 2004Wiley-Liss, Inc.
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