期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 153, 期 1-2, 页码 64-75出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2004.04.007
关键词
astrocytes; cell death; glutamate release; lipopolysaccharide (LPS); proinflammatory cytokines; unconjugated bilirubin
In hyperbilirubinemic newborns, sepsis is considered a risk factor for kernicterus. Evidence shows that injury to astrocytes triggers cytokine release. We examined the effects of unconjugated bilirubin (UCB) alone, or in combination with LPS, on the release of glutamate and cytokines from astrocytes in conditions inducing less than 10% of cell death. UCB leads to an increase of extracellular glutamate and highly enhances the release of TNF-alpha and IL-1beta, while inhibiting the production of IL-6. LPS potentiates immunostimulatory properties of UCB. These results point out the role of cytokines and provide a basis for the significance of sepsis in UCB encephalopathy. (C) 2004 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据