期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 52, 期 8, 页码 935-937出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.52.935
关键词
5-epi-smenospongorine; erythroid differentiation; structure-activity relationship; K562 cells; marine sponge
A new sesquiterpene aminoquinone, 5-epi-smenospongorine, together with nine known sesquiterpene quinone/phenols, was isolated as differentiation-inducing substances to K562 cells into erythroblast from the marine sponge Dactylospongia elegans. The structure-activity relationship study of these compounds clarified that the quinone skeleton is indispensable and the amino group plays an important role for their differentiation-inducing activity to K562 cells into erythroblast.
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