期刊
APPLIED SURFACE SCIENCE
卷 255, 期 12, 页码 6087-6091出版社
ELSEVIER
DOI: 10.1016/j.apsusc.2009.01.083
关键词
Nano-hydroxyapatite; Polyurethane; Scaffold; Degradation; Cytocompatibility
类别
资金
- China 973 fund [2007CB936102]
Porous scaffold containing 30 wt% nano-hydroxyapatite (n-HA) and 70 wt% polyurethane (PU) from castor oil was prepared by a foaming method and investigated by X-ray diffraction (XRD), Fourier transform infrared absorption (FTIR), scanning electron microscopy (SEM) techniques. The results show that n-HA particles disperse homogeneously in the PU matrix. The porous scaffold has not only macropores of 100-800 mu m in size but also a lot of micropores on the walls of macropores. The porosity and compressive strength of scaffold are 80% and 271 kPa, respectively. After soaking in simulated body fluid (SBF), hydrolysis and deposition partly occur on the scaffold. The biological evaluation in vitro and in vivo shows that the n-HA/PU scaffold is non-cytotoxic and degradable. The porous structure provides a good microenvironment for cell adherence, growth and proliferation. The n-HA/PU composite scaffold can be satisfied with the basic requirement for tissue engineering, and has the potential to be applied in repair and substitute of human menisci of the knee-joint and articular cartilage. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.
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