期刊
APPLIED SURFACE SCIENCE
卷 256, 期 5, 页码 1309-1312出版社
ELSEVIER
DOI: 10.1016/j.apsusc.2009.10.030
关键词
Cobalt-coated substrate; Matrix-free target; Laser; Desorption/ionization; Small molecule analysis
类别
资金
- Scientific and Technological Research Council of Turkey
- TUBITAK [105T384]
Small molecule analysis is one of the most challenging issues in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. We have developed a cobalt coated substrate as a target for matrix-free analysis of small molecules in laser desorption/ionization mass spectrometry. Cobalt coating of 60-70 nm thickness has been characterized by scanning electron microscopy, energy dispersive X-ray analysis, X-ray diffraction, and laser induced breakdown spectroscopy. This target facilitates hundreds of samples to be spotted and analyzed without mixing any matrices, in a very short time. This can save a lot of time and money and can be a very practical approach for the analysis of small molecules by laser desorption/ionization mass spectrometry. (C) 2009 Elsevier B. V. All rights reserved.
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