期刊
CLINICAL NUTRITION
卷 23, 期 4, 页码 527-532出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2003.09.013
关键词
enteral nutrition; gastric intolerance; critically ill; mechanical ventilation; pneumonia
Background: Early enteral nutrition (EN) after injury reduces septic complications, but upper digestive intolerance (UDI) occurring immediately post-trauma is a risk factor for pneumonia. Our study aimed to determine whether early intragastric feeding may lead to gastric intolerance and subsequent pneumonia in ventilated multiply injured patients. Methods: This prospective study involved two groups of patients randomized either to immediate intragastric EN, or to delayed intragastric EN started later than 24h after admission. UDI was diagnosed when gastric residual volume, measured with a 50-ml syringe after stopping the feeding for 2 h, exceeded 200 ml at least at two consecutive measurements, and/or when vomiting occurred. Results: Out of 52 patients, 27 were included in the early EN group, and 25 in the delayed-EN group. On day 4, the early EN group received a greater amount of feeding because of intolerance problems occurring in the delayed-EN group (1175 485 ml vs. 803 545 ml). Twenty-five subjects-33% of the early EN patients and 64% of the delayed-EN patients-met the criteria for pneumonia (P = 0.050). On average, patients with pneumonia were older, more severely injured, and therefore required more ventilator days and a longer stay in the intensive care unit than patients without pneumonia. Conclusions: If properly administered, early enteral nutrition can decrease the incidence of upper intestinal intolerance and nosocomial pneumonia in patients with multiple injuries. (C) 2003 Elsevier Ltd. All rights reserved.
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