期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 5, 期 8, 页码 614-625出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1433
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- NIAMS NIH HHS [R01 AR027883-28] Funding Source: Medline
alpha-catenin has often been considered to be a non-regulatory intercellular adhesion protein, in contrast to beta-catenin, which has well-documented dual roles in cell-cell adhesion and signal transduction. Recently, however, alpha-catenin has been found to be important not only in connecting the E-cadherin-beta-catenin complex to the actin cytoskeleton, but also in coordinating actin dynamics and inversely correlating cell adhesion with proliferation. As the number of alpha-catenin-interacting partners increases, intriguing new connections imply even more complex regulatory functions for this protein.
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