期刊
DNA REPAIR
卷 3, 期 8-9, 页码 889-900出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2004.03.029
关键词
ataxia-telangiectasia mutated; cell cycle checkpoint; DNA damage; DNA double-strand breaks; ionizing radiation; p53
Ataxia-telangiectasia mutated (ATM) plays a key role in regulating the cellular response to ionizing radiation. Activation of ATM results in phosphorylation of many downstream targets that modulate numerous damage response pathways, most notably cell cycle checkpoints. In this review, we describe recent developments in our understanding of the mechanism of activation of ATM and its downstream signaling pathways. and explore whether DNA double-strand breaks are the sole activators of ATM and ATM-dependent signaling pathways. (C) 2004 Elsevier B.V. All rights reserved.
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