4.3 Review

Nanoparticle-mediated gene delivery: state of the art

期刊

EXPERT OPINION ON BIOLOGICAL THERAPY
卷 4, 期 8, 页码 1213-1224

出版社

TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.4.8.1213

关键词

block co-polymers; chitosan; gene delivery; lipid; microparticle; nanoparticle; PLGA; polyethylenimines

资金

  1. NHLBI NIH HHS [1R01HL71101-01A2] Funding Source: Medline

向作者/读者索取更多资源

With the development of genomic and proteomic technologies, the prospect for gene therapy has progressed rapidly. This has been partly possible due to the emergence of a diverse array of polymeric and non-polymeric nanoparticles that are being investigated for their ability to deliver genes and drugs. in this review, particles have been pragmatically divided as chitosan-related and chitosan-unrelated nanomaterials. The state of the art in terms of the development, characterisation and evaluation of their in vitro and/or in vivo potential is discussed for each of these various particles. Although substantial progress has been made, the potential of these particles in the clinical arena and human responses remain to be evaluated. it is hoped that this review will provide an impetus for further studies of these particles, with the ultimate intent that one or more of these diverse nanoparticle-based non-viral approaches for gene transfer will translate from 'bench to bedside' in the future.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据