期刊
MOLECULAR NEUROBIOLOGY
卷 30, 期 1, 页码 77-89出版社
SPRINGER
DOI: 10.1385/MN:30:1:077
关键词
monoamine oxiclase B; Parkinson's disease; aging; free radicals; deprenyl; genetic polymorphisms; mitochondrial dysfunction
The catecholamine-oxidizing enzyme monoamine oxidase-B (MAO-B) has been hypothesized to be an important determining factor in the etiology of both normal aging and age-related neurological disorders such as Parkinson's disease (PD). Catalysis of substrate by the enzyme produces H2O2 which is a primary originator of oxidative stress which in turn can lead to cellular damage. MAO-B increases with age as does predisposition towards PD which has also been linked to increased oxidative stress. Inhibition of MAO-B, along with supplementation of lost dopamine via L-DOPA, is one of the major antiparkinsonian therapies currently in use. In this review, we address several factors contributing to a possible role for MAO-B in normal brain aging and neurological disease and also discuss the use of MAO-B inhibitors as drug therapy for these conditions.
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