期刊
DRUG RESISTANCE UPDATES
卷 7, 期 4-5, 页码 233-244出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.drup.2004.07.001
关键词
Plasmodium falciparum; malaria; artemisinin; endoperoxides
Artemisinins form the most important class of antimalarial currently available, particularly because they are effective against parasites resistant to almost all the other classes. Their mechanism of action is controversial. Some aspects of this controversy are reviewed here. Whilst there is no clinical resistance yet identified to artemisinins, the potential to examine the relationship between polymorphisms in PfATP6 (a target of artemisinins) in multidrug resistant isolates of Plasmodium falciparum, is also discussed. (C) 2004 Elsevier Ltd. All rights reserved.
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