期刊
QUARTERLY REVIEWS OF BIOPHYSICS
卷 37, 期 3-4, 页码 197-284出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033583505004026
关键词
-
类别
资金
- NCI NIH HHS [U19CA87427, CA 68262] Funding Source: Medline
- NCRR NIH HHS [RR-00995] Funding Source: Medline
- NIGMS NIH HHS [GM47467, P01 GM047467] Funding Source: Medline
Translation, the process of mRNA-encoded protein synthesis, requires a complex apparatus, composed of the ribosome. tRNAs and additional protein factors, including aminoacyl tRNA synthetases. The ribosome provides the platform for proper assembly of mRNA, tRNAs and protein factors and carries the peptidyl-transferase activity, It consists of small and large subunits. The ribosomes are ribonucleoprotein particles with a ribosomal RNA core, to which multiple rilbosomal proteins are bound. The sequence and structure of ribosomal RNAs, tRNAs, some of the ribosomal proteins and some of the additional protein factors are conserved in all kingdoms, underlying the common origin of the translation apparatus. Translation can be subdivided into several steps: initiation, elongation, termination and recycling. Of these, initiation is the most complex and the most divergent among the different kingdoms of life. A great amount of new structural, biochemical and genetic information on translation initiation has been accumulated in recent years, which led to the realization that initiation also shows a great degree of conservation throughout evolution. In this review, we summarize the available structural and functional data on translation initiation in the context of evolution, drawing parallels between eubacteria, archaea, and eukaryotes, We will start with an overview of the ribosome structure and of translation in general, placing emphasis on factors and processes with relevance to initiation. The major steps in initiation and the factors involved will be described, followed by discussion of the structure and function of the individual initiation factors throughout evolution. We will conclude with a summary of the available information on the kinetic and thermodynamic aspects of translation initiation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据