期刊
MOLECULAR IMMUNOLOGY
卷 41, 期 10, 页码 979-984出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2004.06.023
关键词
HIV-1; monocyte-derived macrophages; HIV-1 transgenic rat
资金
- NCRR NIH HHS [G12 RR017581] Funding Source: Medline
- NINDS NIH HHS [NS31867, NS31857] Funding Source: Medline
- PHS HHS [MS29494] Funding Source: Medline
It has been developed an HIV type 1 transgenic rat model (HIV-1 Tg Rat) which contains a gag-pol-deleted HIV-1 provirus regulated by the viral LTR promoter. Altought it harbors a non infectious provirus, efficient viral expression occurs in different tissues and disease manifestations as well as immune-response alterations and pathologies similar to humans can be observed. Regulation of HIV-1 expression is influenced by various cellular factors and it is well known that macrophages are one of the major reservoir of HIV-1 infection and a vehicle for virus spread to other tissues. Purpose of our work was to establish an antigen presenting cells (monocyte-derived macrophages, MDM) ex vivo model from these HIV-1 transgenic rats. This model can be used to study function of HIV-infected MDM and their behavior like HIV-1 reservoir. Ultimately, these studies may be helpful in defining approaches to control HIV-1 spread. (C) 2004 Elsevier Ltd. All rights reserved.
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