期刊
AMERICAN JOURNAL OF HYPERTENSION
卷 17, 期 8, 页码 701-706出版社
OXFORD UNIV PRESS
DOI: 10.1016/j.amjhyper.2004.03.674
关键词
blood pressure; hypertension; fermented milk; tripeptides; randomized controlled trial
Background: A double-blind randomized controlled trial was carried out to assess the effect of sour milk, containing two tripeptides (valine-proline-proline and isoleucine-proline-proline), on blood pressure (BP). Methods: A total of 46 borderline hypertensive men aged 23 to 59 years were recruited at their workplace for this trial. Subjects were randomly allocated into two groups; sour milk drink group (S-group, n = 23) and placebo (acidified milk) drink group (P-group, n = 23) for 4 weeks. Blood pressure was measured twice at each occasion by a physician, at the health center of the company, with a mercury sphygmomanometer at baseline, 2 and 4 weeks. Statistical analysis was performed by SPSS 10.0J. Results: The S-group and P-group showed no significant difference in baseline systolic BP (mean [SD], S: 147.6 [9.6], P: 145.3 [13.0]) or diastolic BP (S: 95.3 [9.91, P: 91.5 [9.6]). In the S-group, change in systolic BP at 2 and 4 weeks were -4.3 mm Hg (95% confidence interval [CI] -8.3 to -0.4; P =.032) and -5.2 turn Hg (95% Cl -10.1 to -0.3; P =.039), both statistically significant. Diastolic BP showed change from -1.7 mm Hg (95% Cl -5.4 to 2.0) at 2 weeks and -2.0 (95% CI -5.4 to 1.5) at 4 weeks, respectively. In the P-group, change in systolic BP was -0.5 (95% Cl -5.8 to 4.8) at 2 weeks and -3.7 (95% Cl -8.3 to 0.9) at 4 weeks and change in diastolic BP was -0.6 (95% Cl -4.7 to 3.6) at 2 weeks and -0.3 (95% Cl -3.9 to 3.3) at 4 weeks, which were not statistically significant. Conclusions: This trial demonstrated the beneficial effect of sour milk on BP in borderline hypertensive men who were not taking antihypertensive medication. (C) 2004 American Journal of Hypertension, Ltd.
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